{"id":2398,"date":"2016-08-08T22:53:06","date_gmt":"2016-08-08T22:53:06","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=2398"},"modified":"2016-08-10T22:07:12","modified_gmt":"2016-08-10T22:07:12","slug":"dopajul-viitorului-manipularea-genetica","status":"publish","type":"post","link":"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/08\/dopajul-viitorului-manipularea-genetica\/","title":{"rendered":"Dopajul viitorului: manipularea genetic\u0103"},"content":{"rendered":"<p lang=\"ro-RO\" align=\"JUSTIFY\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">Pentru a c\u00ee\u015ftiga medalii, unii sportivi recurg la substan\u0163e fortifiante, risc\u00eendu-\u015fi s\u0103n\u0103tatea. \u00centr-un studiu efectuat \u00een anii 1980 \u0219i 1990, jum\u0103tate dintre sportivii de elit\u0103 s-au declarat gata s\u0103 ia un medicament nedetectabil pentru a c\u00ee\u0219tiga, chiar dac\u0103 stimulentul i-ar fi putut omor\u00ee \u00een cinci ani. <\/span><\/span><!--more--><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">Probabil dopingul a existat dintotdeauna, nu este ceva nou. Grecii antici au m\u00eencat testicule de oi, \u00een timp ce medicul Galen prescria gladiatorilor copite fierte de m\u0103gari etiopieni, aromatizate cu petale de trandafir. La sf\u00eer\u0219itul secolului XIX, sportivii au folosit ca stimulente cocaina si heroina, uneori amestecate (\u201eSpeedball\u201d). Un biciclist a murit \u00een timpul unei curse, \u00een 1886, dup\u0103 ce a luat acest amestec. \u00cen 1904, Thomas Hicks a alergat la maratonul olimpic dup\u0103 ce a luat un cocteil de coniac \u0219i stricnin\u0103 (otrav\u0103 pentru roz\u0103toare). A c\u00ee\u0219tigat cursa, dar a fost la un pas de moarte. \u00cen 1930, un club de fotbal britanic se baza pe injec\u021bii cu extracte din glande de maimu\u021b\u0103. Nici ast\u0103zi problema nu a disp\u0103rut, dar metodele s\u00eent mai sofisticate: transfuzii de s\u00eenge, steroizi, hormoni de cre\u015ftere. Oare unde se va ajunge? Oamenii de \u015ftiin\u0163\u0103 presupun c\u0103 sportivii vor accepta s\u0103 le fie prelucrate genele, pentru a fi mai puternici, mai rapizi, mai rezisten\u0163i. Dar la acest nivel nu s-a ajuns \u00eenc\u0103. <\/span><\/span><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">Xavier Bigard, consilier \u0219tiin\u021bific la Agen\u021bia francez\u0103 de lupt\u0103 \u00eempotriva dopajului \u015fi pre\u0219edinte al Societ\u0103\u021bii Franceze de Medicin\u0103 \u015fi Sport explic\u0103 dac\u0103 performan\u021ba sportiv\u0103 poate fi \u00eembun\u0103t\u0103\u0163it\u0103 prin manipulare genetic\u0103.<\/span><\/span><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\">\u201e<span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\"><em>Teoretic, da! Prin dou\u0103 moduri: introducerea de noi gene \u00een genom sau neutralizarea amprentei genelor \u021bint\u0103. Studiile derulate pe durata a cinci ani au ar\u0103tat c\u0103 includerea genei PEPCK \u00een musculatura scheletic\u0103 a \u015foarecilor poate multiplica performan\u021bele fizice de 50 de ori. S-a ar\u0103tat, de asemenea, c\u0103 includerea fragmentelor de ADN poate neutraliza produc\u021bia miostatinei, o peptid\u0103 secretat\u0103 de mu\u0219chi pentru a limita cre\u0219terea. Rezultatul: o cre\u0219tere brusc\u0103 \u0219i rapid\u0103 a masei musculare<\/em>.\u201d<\/span><\/span><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">Aceste tehnici nu s\u00eent practicate pe oameni, dar nu are motive etice, nici de s\u0103n\u0103tate, cum ar fi dezvoltarea cancerului. \u201e<em>Blocajul este tehnologic: nu \u015ftim s\u0103 modific\u0103m expresia genomului uman \u00eentr-un astfel de \u021besut mare cum e mu\u0219chiul. Dar cercetarea clinic\u0103 continu\u0103, s\u00eent mobilizate resurse colosale. Pentru c\u0103 aceast\u0103 tehnic\u0103 ar fi de folos \u00een primul r\u00eend pacien\u021bilor cu boli genetice severe<\/em>\u201d, precizeaz\u0103 Bigard. <\/span><\/span><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">Cercetatorii vor reu\u0219i s\u0103 realizeze dopaje genetice peste 10 sau 30 de ani? Imposibil de spus, dar atunci c\u00eend primele protocoale terapeutice vor fi validate la om, lumea sportului va avea motive \u00eentemeiate s\u0103-\u015fi fac\u0103 griji. \u201e<em>Aceste pericole trebuie anticipate. Agen\u021bia francez\u0103 de lupt\u0103 \u00eempotriva dopajului a contribuit la dezvoltarea cercet\u0103rii pentru detectarea urmelor de <span style=\"font-family: Times New Roman,serif;\">\u00ab<\/span>vector viral<span style=\"font-family: Times New Roman,serif;\">\u00bb<\/span>, utilizat pentru a transfera gene sau a modifica expresia genomului. O alt\u0103 strategie ar fi de a identifica genele transferate gra\u0163ie configura\u021biei lor spa\u021biale particulare, \u00een cea mai mare parte circular\u0103<\/em>\u201d.<\/span><\/span><\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\">Sursa: <a href=\"http:\/\/www.sciencesetavenir.fr\/sante\/20160805.OBS5868\/jeux-olympiques-de-rio-le-dopage-genetique-existe-t-il.html\" target=\"_blank\"><span style=\"font-family: Times New Roman,serif;\"><span style=\"font-size: medium;\">sciencesetavenir.fr<\/span><\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pentru a c\u00ee\u015ftiga medalii, unii sportivi recurg la substan\u0163e fortifiante, risc\u00eendu-\u015fi s\u0103n\u0103tatea. \u00centr-un studiu efectuat \u00een anii 1980 \u0219i 1990,<\/p>\n","protected":false},"author":4,"featured_media":2399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[98,107,91],"tags":[1485,1486,1489,1491,1487,1422,1493,1492,137,1488,1490],"class_list":["post-2398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-controverse","category-sport","category-stiri","tag-dopaj","tag-dopaj-genetic","tag-energizante","tag-jocurile-olimpice","tag-manipularea-genelor","tag-mutatii-genetice","tag-olimpiada","tag-rio-2016","tag-sport","tag-sportivi-olimpiada","tag-stimulente"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - 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