{"id":3041,"date":"2016-09-03T20:36:47","date_gmt":"2016-09-03T20:36:47","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=3041"},"modified":"2016-09-03T20:37:03","modified_gmt":"2016-09-03T20:37:03","slug":"anticorp-care-vindeca-boala-alzheimer-in-stadiu-incipient","status":"publish","type":"post","link":"http:\/\/doctorexpres.ro\/index.php\/2016\/09\/03\/anticorp-care-vindeca-boala-alzheimer-in-stadiu-incipient\/","title":{"rendered":"Anticorp care vindec\u0103 boala Alzheimer \u00een stadiu incipient"},"content":{"rendered":"

Aducanumab, un anticorp direc\u021bionat \u00eempotriva proteinei beta-amiloid, a ajutat la \u00eencetinirea declinului cognitiv la pacien\u0163ii cu o form\u0103 timpurie a bolii Alzheimer<\/a>, potrivit unui studiu realizat \u00een SUA. <\/p>\n

Acest medicament a fost dezvoltat de compania farmaceutic\u0103 Biogen (Cambridge, Massachusetts). Sub rezerva confirm\u0103rii, aceste rezultate sus\u021bin ipoteza c\u0103 acumularea \u00een timp a peptidei beta-amiloid este un factor determinant al declinului cognitiv observat \u00een boala Alzheimer<\/a>.<\/p>\n

Publicat \u00een revista \u201eNature\u201d, studiul a implicat 165 de pacien\u0163i cu predemen\u021b\u0103<\/a> (simptomele bolii nu s-au dezvoltat) sau cu demen\u0163\u0103 u\u015foar\u0103. Toate cazurile au prezentat pl\u0103ci amiloide, confirmate de imaginile ob\u021binute prin tomografie cu emisie de pozitroni (PET). Subiec\u0163ii au primit trei doze diferite de anticorp (3, 6 \u0219i 10 mg\/kg) sau placebo, sub form\u0103 de injec\u021bie intravenoas\u0103, o dat\u0103 pe lun\u0103. Dup\u0103 un an de tratament, cercet\u0103torii au observat la pacien\u021bii trata\u021bi cu anticorp reducerea pl\u0103cilor de amiloid \u00een creier. Aceast\u0103 sc\u0103dere a fost dependent\u0103 at\u00eet de doza de anticorpi administrat\u0103, c\u00eet \u0219i de durata tratamentului. Medicii au constatat o \u00eencetinire a declinului cognitiv.
\nCu toate acestea, trebuie subliniat faptul c\u0103 acest studiu preliminar, pe un num\u0103r mic de pacien\u021bi, a fost conceput pentru a evalua siguran\u021ba \u0219i toleran\u021ba la anticorp \u0219i pentru a detecta un posibil efect asupra nivelurilor intracerebrale de beta-peptid amiloid. Cercetarea nu a avut scopul de a determina eficien\u0163a terapeutic\u0103 printr-o statistic\u0103 relevant\u0103.
\nPotrivit autorilor, \u00een studiul preclinic, s-a observat c\u0103 mecanismul responsabil pentru dispari\u021bia pl\u0103cilor de amiloid indus\u0103 de anticorpul monoclonal ar include capacitatea acestuia de a recruta celulele microgliale, astfel \u00eenc\u00eet s\u0103 elimine aceste depozite anormale. Celulele microgliale \u00eencapsuleaz\u0103 zona central\u0103 a pl\u0103cilor de amiloid.
\n\u00cen studiul clinic, s-au observat dureri mari de cap<\/a> la pacien\u021bii care au primit doze mai mari de anticorpi. Acest efect secundar tinde s\u0103 dispar\u0103 \u00een decurs de 4 p\u00een\u0103 la 12 s\u0103pt\u0103m\u00eeni. Printre cei 27 de pacien\u0163i cu migrene, 15 au continuat tratamentul, ceilal\u0163i l-au \u00eentrerupt. Acest efect secundar a fost mai frecvent la pacien\u021bii cu alela Apo\u03b5E4, factor major de risc genetic pentru boala Alzheimer<\/a>.<\/p>\n

\u201eS\u00eent optimist\u0103, dar prudent\u0103 \u00een leg\u0103tur\u0103 cu acest tratament, deoarece multe medicamente au trecut primele teste cu brio \u00eenainte de a ceda \u00een studiile de anvergur\u0103<\/em>\u201d, a spus dr. Tara Speier-Jones, de la Universitatea din Edinburgh (Sco\u021bia).<\/p>\n

Sursa: sciencesetavenir.fr<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Aducanumab, un anticorp direc\u021bionat \u00eempotriva proteinei beta-amiloid, a ajutat la \u00eencetinirea declinului cognitiv la pacien\u0163ii cu o form\u0103 timpurie a<\/p>\n","protected":false},"author":4,"featured_media":1614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[96,818,91],"tags":[2964,2967,2120,2965,2969,2968,2966,2963,819],"class_list":["post-3041","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boli","category-creier-si-sistem-nervos","category-stiri","tag-anticorp-care-trateaza-dementa","tag-beta-amiloid","tag-boala-alzheimer","tag-dementa-timpurie","tag-descoperire-alzheimer","tag-medicament-alzheimer","tag-placi-amiloide","tag-predementa","tag-tratament-alzheimer"],"yoast_head":"\nAnticorp care vindec\u0103 boala Alzheimer \u00een stadiu incipient - 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