{"id":4734,"date":"2016-12-15T22:40:30","date_gmt":"2016-12-15T22:40:30","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=4734"},"modified":"2016-12-15T22:40:30","modified_gmt":"2016-12-15T22:40:30","slug":"cercetatorii-au-reusit-sa-inverseze-imbatrinirea","status":"publish","type":"post","link":"http:\/\/doctorexpres.ro\/index.php\/2016\/12\/15\/cercetatorii-au-reusit-sa-inverseze-imbatrinirea\/","title":{"rendered":"Cercet\u0103torii au reu\u015fit s\u0103 inverseze \u00eemb\u0103tr\u00eenirea"},"content":{"rendered":"

Oamenii de \u015ftiin\u0163\u0103 de la Institutul Salk din SUA au descoperit c\u0103 semnele distinctive ale b\u0103tr\u00eene\u021bii<\/span><\/span> pot fi inversate prin reprogramare genetic\u0103, iar durata vie\u0163ii poate fi prelungit\u0103 cu 30%. <\/span><\/span><\/p>\n

Studiul a ob\u0163inut celule ale pielii care ar\u0103tau \u015fi se comportau ca \u015fi cum ar fi tinere din nou, dar a dus \u015fi la \u00eentinerirea \u015foarecilor care sufereau de \u00eemb\u0103tr\u00eenire prematur\u0103, combaterea semnelor de \u00eemb\u0103tr\u00eenire<\/a> \u0219i cre\u0219terea duratei de via\u021b\u0103 a animalelor cu 30%. \u201eStudiul nostru arat\u0103 c\u0103 \u00eemb\u0103tr\u00eenirea nu trebuie s\u0103 progreseze \u00eentr-o direc\u021bie unic\u0103. Are plasticitate \u015fi, cu o modulare atent\u0103, \u00eemb\u0103tr\u00eenirea <\/a>ar putea fi inversat\u0103<\/em>\u201d, spune prof. Juan Carlos Izpisua Belmonte, autorul principal al studiului. <\/span><\/span><\/p>\n

Pe m\u0103sur\u0103 ce oamenii din societ\u0103\u021bile moderne tr\u0103iesc mai mult<\/a>, riscul de a dezvolta boli legate de v\u00eerst\u0103 cre\u015fte. De fapt, datele arat\u0103 c\u0103 cel mai mare factor de risc pentru boli de inim\u0103, cancer <\/a>si boli neurodegenerative este v\u00eersta \u00eenaintat\u0103. <\/span><\/span><\/p>\n

Prin reprogramare celular\u0103, patru gene cunoscute sub numele de factorii Yamanaka permit oamenilor de \u015ftiin\u0163\u0103 s\u0103 converteasc\u0103 orice celul\u0103 \u00een celule stem induse pluripotente (iPSCs). Acestea s\u00eent capabile de divizare pe termen nelimitat \u0219i s\u0103 devin\u0103 orice tip de celule din corpul nostru. <\/span><\/span>\u201eCeea ce au observat \u0219i alte laboratoare de celule stem este c\u0103, atunci c\u00eend inducem reprogramarea celular\u0103, celulele arat\u0103 mai tinere<\/a>. Urm\u0103toarea \u00eentrebare a fost dac\u0103 am putea induce acest proces de \u00eentinerire la un animal viu<\/em>\u201d, explic\u0103 Alejandro Ocampo, cercet\u0103tor asociat. <\/span><\/span><\/p>\n

Cu toate c\u0103 diviziunea celular\u0103 rapid\u0103 este specific\u0103 embrionilor \u00een cre\u0219tere, la adul\u021bi o astfel de cre\u0219tere este unul dintre semnele distinctive ale cancerului. Pe de alt\u0103 parte, cu num\u0103r mare de celule revenite la starea embrionar\u0103, ar putea conduce la insuficien\u0163a organului adult \u015fi, \u00een cele din urm\u0103, moarte. Din aceste motive, echipa de savan\u0163i s-au \u00eentrebat dac\u0103 ar putea evita cancerul induc\u00eend factorii Yamanaka pentru o perioad\u0103 scurt\u0103 de timp. <\/span><\/span><\/p>\n

Pentru a afla, au apelat la o boal\u0103 genetic\u0103 rar\u0103 numita progeria, caracterizat\u0103 prin semne de \u00eemb\u0103tr\u00eenire<\/a>, inclusiv deprecierea ADN-ului, disfunc\u021bia organelor \u015fi durat\u0103 de via\u0163\u0103<\/a> scurtat\u0103 dramatic. M\u0103rcile epigenetice, cele care protejeaz\u0103 genomul, s\u00eent prematur dereglate la \u015foarecii \u015fi oamenii cu progeria. Foarte important, m\u0103rcile epigenetice s\u00eent modificate \u00een timpul reprogram\u0103rii celulare. <\/span><\/span><\/p>\n

Folosind celule din pielea \u015foarecilor cu progeria, cercet\u0103torii au indus factorii Yamanaka pentru o scurt\u0103 perioad\u0103 de timp. C\u00eend au examinat celulele folosind metode de laborator standard, celulele au prezentat invers\u0103ri multiple ale semnelor de \u00eemb\u0103tr\u00eenire<\/a>, f\u0103r\u0103 a-\u0219i pierde identitatea, deci f\u0103r\u0103 a deveni poten\u0163ial canceroase. <\/span><\/span><\/p>\n

\u00cencurajat\u0103 de acest rezultat, echipa de oameni de \u015ftiin\u0163\u0103 a folosit aceea\u0219i metod\u0103 la \u015foarecii vii cu progeria. Rezultatele au fost uimitoare. Comparativ cu \u0219oarecii netrata\u021bi, \u0219oarecii reprograma\u0163i ar\u0103tau mai tineri, func\u021bia lor cardiovascular\u0103 \u0219i a altor organe se \u00eembun\u0103t\u0103\u0163ise \u015fi, cel mai surprinz\u0103tor din toate, au tr\u0103it cu 30% mai mult<\/a>, dar nu au dezvoltat cancer.
\n<\/span><\/span><\/p>\n

\u201eAceasta arat\u0103 c\u0103 modific\u0103rile epigenetice, cel pu\u021bin par\u021bial, dirijeaz\u0103 \u00eemb\u0103tr\u00eenirea. Aceasta ne ofer\u0103 perspective interesante de g\u0103sire a unor c\u0103i pentru a \u00eent\u00eerzia \u00eemb\u0103tr\u00eenirea celular\u0103<\/em>\u201d, spune co-autorul Paloma Martinez-Redondo.<\/span><\/span><\/p>\n

\u00cen cele din urm\u0103, exper\u0163ii de la Institutul Salk au aplicat metoda \u015fi la \u015foarecii normali. La aceste animale, inducerea ciclic\u0103 a factorilor Yamanaka a condus la \u00eembun\u0103t\u0103\u021birea capacit\u0103\u021bii de regenerare a pancreasului \u0219i mu\u0219chilor. <\/span><\/span><\/p>\n

Cercet\u0103torii cred cu t\u0103rie c\u0103 inducerea modific\u0103rilor epigenetice prin substan\u021be chimice sau molecule mici poate fi abordarea cea mai promi\u021b\u0103toare pentru a \u00eentineri omul. Ei apreciaz\u0103 c\u0103 poate dura p\u00een\u0103 la 10 de ani p\u00een\u0103 c\u00eend tratamentul va fi inclus \u00een studiile clinice.<\/span><\/span><\/p>\n

Sursa: medicalxpress.com<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Oamenii de \u015ftiin\u0163\u0103 de la Institutul Salk din SUA au descoperit c\u0103 semnele distinctive ale b\u0103tr\u00eene\u021bii pot fi inversate prin<\/p>\n","protected":false},"author":4,"featured_media":4735,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[554,91,103],"tags":[5835,5827,5829,5837,5833,5836,138,5830,5831,5828,5832,5834],"class_list":["post-4734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pielea","category-stiri","category-varstnici","tag-diviziune-celulara-rapida","tag-factori-yamanaka","tag-imbatranire-celulara","tag-imbatranire-prematura","tag-intinerire-descoperire","tag-ipscs","tag-longevitate","tag-modificari-epigenetice","tag-progeria","tag-regenerare-pancreas","tag-reprogramare-genetica","tag-semne-de-imbatranire"],"yoast_head":"\nCercet\u0103torii au reu\u015fit s\u0103 inverseze \u00eemb\u0103tr\u00eenirea - 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