{"id":5973,"date":"2017-04-04T19:50:45","date_gmt":"2017-04-04T19:50:45","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=5973"},"modified":"2017-04-04T19:50:45","modified_gmt":"2017-04-04T19:50:45","slug":"asa-se-explica-de-ce-cancerului-nu-i-plac-sportivii","status":"publish","type":"post","link":"http:\/\/doctorexpres.ro\/index.php\/2017\/04\/04\/asa-se-explica-de-ce-cancerului-nu-i-plac-sportivii\/","title":{"rendered":"A\u015fa se explic\u0103 de ce cancerului nu-i plac sportivii"},"content":{"rendered":"<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Cercet\u0103torii nu au descifrat <span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\">\u00eenc\u0103<\/span><\/span> mecanismul oncogenezei, procesul prin care celulele normale devin canceroase. <\/span><\/span><\/span><!--more--><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Un nou studiu se concentreaz\u0103 pe lactat, o molecul\u0103 produs\u0103 \u00een timpul <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/02\/28\/sportul-intensiv-scade-libidoul-masculin\/\" target=\"_blank\">antrenamentelor intense<\/a>, \u0219i explic\u0103 rolul s\u0103u \u00een formarea \u015fi dezvoltarea celulelor canceroase. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Lactatul este un produs secundar al procesului chimic cunoscut sub numele de glicoliz\u0103 (transformarea <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/03\/10\/6-adevaruri-negre-despre-zaharul-alb\/\" target=\"_blank\">zah\u0103rului<\/a> sau <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/02\/21\/excesul-de-fructoza-poate-afecta-ficatul-copiilor\/\" target=\"_blank\">glucozei<\/a> \u00een molecule mai mici, cu scopul de a produce energie). \u00cen timpul activit\u0103\u021bii fizice intense, lactatul se acumuleaz\u0103 \u00een \u021besuturi \u0219i s\u00eenge, ceea ce poate duce uneori la sc\u0103derea performan\u0163elor fizice \u015fi rigiditate <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/06\/15\/exercitiile-pentru-muschi-prelungesc-viata\/\" target=\"_blank\">muscular\u0103<\/a>. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">La \u00eenceputul secolului XX, omul de \u0219tiin\u021b\u0103 german Otto Warburg a observat c\u0103 celulele canceroase consum\u0103 glucoz\u0103 mai mult\u0103 dec\u00eet celulele normale. A\u0219a-numitul efect Warburg se refer\u0103 la faptul c\u0103 <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/23\/fara-lipide-celulele-canceroase-mor\/\" target=\"_blank\">celulele canceroase<\/a> produc mai mult lactat, comparativ cu celulele normale. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Noua cercetare, condus\u0103 de Inigo San Millan, director al Departamentului de Performan\u021be Sportive de la Universitatea din Colorado, sugereaz\u0103 c\u0103 molecula este \u201esingurul compus metabolic implicat \u0219i necesar\u201d \u00een cele cinci etape, care succed carcinogeneza. Studiul examineaz\u0103 rolul lactatului \u00een angiogenez\u0103 (procesul prin care se formeaz\u0103 noi <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/02\/robotelul-care-curata-arterele-infundate\/\" target=\"_blank\">vase de s\u00eenge<\/a> \u00een interiorul tumorilor), \u00een capacitatea <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/12\/09\/descoperire-majora-celulele-canceroase-pot-fi-determinate-sa-se-autodistruga\/\" target=\"_blank\">celulelor canceroase <\/a>de a eluda r\u0103spunsul imun al organismului, precum \u0219i \u00een metastaz\u0103 \u0219i autometabolism. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Lucrarea a explicat modul cum, \u00een metastaz\u0103, lactatul ajut\u0103 la crearea unui micromediu acid \u00een afara <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/12\/13\/studiu-prin-post-celulele-canceroase-redevin-normale\/\" target=\"_blank\">celulei canceroase<\/a>, care sprijin\u0103 r\u0103sp\u00eendirea celulelor canceroase. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">\u00cen cele din urm\u0103, studiul exploreaz\u0103 leg\u0103tura dintre lactat \u0219i componentele <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/08\/dopajul-viitorului-manipularea-genetica\/\" target=\"_blank\">genetice<\/a>. S-a formulat ipoteza c\u0103 o triad\u0103 de factori de transcriere frecvent \u00eent\u00eelni\u0163i \u00een cele mai multe forme de cancer, HIF-1, cMYC \u015fi p53 declan\u0219eaz\u0103 \u0219i perpetueaz\u0103 reglementarea eronat\u0103 a lactatului. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Rolul esen\u021bial al lactatului \u00een formarea celulelor canceroase ar putea explica de ce oamenii care fac sport \u00een mod regulat prezint\u0103 un risc mai mic de a dezvolta <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/03\/08\/exercitiile-fizice-mai-eficiente-decit-medicamentele-in-refacerea-pacientilor-cu-cancer\/\" target=\"_blank\">cancer<\/a>. La<a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/10\/18\/ce-se-intimpla-intr-un-corp-care-face-sport\/\" target=\"_blank\"> sportivi<\/a> \u0219i la cei care lucreaz\u0103 \u00een aer liber, organismul este instruit s\u0103 transforme \u00een mod eficient lactatul \u00eentr-o surs\u0103 de energie pentru organism, astfel oprindu-se acumularea acestuia \u00een exces. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Pe baza rezultatelor, cercet\u0103torii speculeaz\u0103 c\u0103 un <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/01\/20\/statul-pe-scaun-le-imbatrineste-pe-femei\/\" target=\"_blank\">stil de via\u021b\u0103 sedentar<\/a>, combinat cu prea mult zah\u0103r, poate duce la o acumulare excesiv\u0103 de lactat, stabilind astfel mediul propice pentru <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/01\/31\/12-alimente-care-tintesc-cancerul\/\" target=\"_blank\">cancer<\/a>. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\">\u201e<span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\"><em>Cu aceast\u0103 lucrare, deschidem o u\u0219\u0103 cu totul nou\u0103 \u00een \u00een\u0163elegerea cancerului, care arat\u0103 pentru prima dat\u0103 c\u0103 lactatul este nu numai prezent, ci obligatoriu pentru fiecare pas \u00een dezvoltarea maladiei<\/em>\u201d, spune San Millan.<\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">\u00cen viitorul apropiat, cercet\u0103torii vor studia efectul programelor de <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/02\/09\/exercitiile-de-hot-yoga-pot-fi-periculoase\/\" target=\"_blank\">exerci\u0163ii <\/a>fizice adaptate la pacien\u021bii cu cancer. Ei studiaz\u0103 deja liniile de celule cu cancer de s\u00een. San Millan sper\u0103 c\u0103, \u00een cele din urm\u0103, cercetarea va ajuta la dezvoltarea de medicamente care stopeaz\u0103 acumul\u0103rile de lactat. <\/span><\/span><\/span><\/p>\n<p align=\"JUSTIFY\"><span style=\"font-family: Times new roman,serif;\"><span style=\"font-size: medium;\"><span lang=\"ro-RO\">Sursa: <a href=\"http:\/\/www.medicalnewstoday.com\/articles\/316438.php\" target=\"_blank\">medicalnewstoday.com<\/a><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cercet\u0103torii nu au descifrat \u00eenc\u0103 mecanismul oncogenezei, procesul prin care celulele normale devin canceroase.<\/p>\n","protected":false},"author":4,"featured_media":5976,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[96,93,105,107,91],"tags":[8289,8285,8291,1559,8287,8283,8290,8278,8279,8286,8284,8277,8276,8282,8288,8280,8281],"class_list":["post-5973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boli","category-cancer","category-miscare-si-natura","category-sport","category-stiri","tag-acumulare-lactat","tag-angiogeneza","tag-cancer-lactat","tag-celule-canceroase","tag-cmyc","tag-efect-warburg","tag-exces-de-lactat","tag-formarea-celulelor-canceroase","tag-glicoliza","tag-hif-1","tag-inigo-san-millan","tag-lactat","tag-oncogeneza","tag-otto-warburg","tag-p53","tag-performante-fizice","tag-rigiditate-musculara"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - 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