{"id":7750,"date":"2022-09-20T10:28:14","date_gmt":"2022-09-20T07:28:14","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=7750"},"modified":"2022-09-20T10:28:03","modified_gmt":"2022-09-20T07:28:03","slug":"singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase","status":"publish","type":"post","link":"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/","title":{"rendered":"Singura molecul\u0103 care determin\u0103 moartea celulelor pulmonare canceroase"},"content":{"rendered":"

Oamenii de \u015ftiin\u0163\u0103 au descoperit c\u0103 o molecul\u0103 numit\u0103 mIR-124 joac\u0103 un rol important \u00een aflarea r\u0103spunsului la \u00eentrebarea dac\u0103 un anumit tip de celule canceroase r\u0103spunde la agen\u0163i chimioterapici.<\/p>\n

Potrivit datelor furnizate de Centrele pentru Controlul \u0219i Prevenirea Bolilor, cancerul pulmonar<\/a> este principala cauz\u0103 a decesului cauzat de cancer \u00een Statele Unite. Cancerul pulmonar <\/a>cu celule mici (NSCLC) este cel mai frecvent tip de cancer pulmonar, reprezent\u00eend 85% din diagnosticele de cancer pulmonar. Tratamentele existente nu pot vindeca acest tip de cancer.<\/p>\n

Cu toate acestea, un nou studiu condus de dr. Anurag Singh de la Universitatea de Medicin\u0103 din Boston a descoperit c\u0103 o molecul\u0103 indic\u0103 dac\u0103 unele dintre cele mai rezistente celule canceroase<\/a> mor sau nu \u00een urma chimioterapiei<\/a>. Constat\u0103rile cercet\u0103torilor au fost publicate \u00een revista Science Signaling.<\/p>\n

\u00cen NSCLC, unele celule epiteliale<\/a> din c\u0103ptu\u0219eala \u021besutului pulmonar<\/a> se transform\u0103 \u00een celule mezenchimale, care pot deveni celule canceroase, invad\u00eend \u021besuturi s\u0103n\u0103toase \u0219i form\u00eend tumori<\/a>. Celulele mezenchimale prezint\u0103 muta\u021bii \u00een gena KRAS, care joac\u0103 un rol important \u00een controlul diviziunii celulare. KRAS este o proto-oncogen\u0103, adic\u0103 este susceptibil\u0103 la muta\u021bii care \u00eei permit s\u0103 promoveze dezvoltarea cancerului. Celulele mezenchimale canceroase <\/a>rezist\u0103 la moartea celulelor programate dup\u0103 expunerea la chimioterapie.<\/p>\n

Cercetat\u0103rii au descoperit c\u0103 o molecul\u0103 numit\u0103 mIR-124 determin\u0103 moartea celulelor programate \u00een \u0163esuturile care au trecut prin transformarea epitelio-mezenchimal\u0103. Dr. Singh \u0219i echipa au reu\u0219it s\u0103 identifice rolul miR-124 prin studierea modelelor celulare de la tumorile NSCLC \u00een laborator.<\/p>\n

Cercet\u0103torii sper\u0103 c\u0103 aceste concluzii pot duce la studii preclinice de tratamente<\/a> \u00eembun\u0103ta\u0163ite pentru NSCLC.<\/p>\n

Sursa: medicalnewstoday.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Oamenii de \u015ftiin\u0163\u0103 au descoperit c\u0103 o molecul\u0103 numit\u0103 mIR-124 joac\u0103 un rol important \u00een aflarea r\u0103spunsului la \u00eentrebarea dac\u0103<\/p>\n","protected":false},"author":4,"featured_media":4660,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1008,96,93,91],"tags":[1888,11578,11580,5554,11579,11581,11577,9700,11582],"class_list":["post-7750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aparatul-respirator","category-boli","category-cancer","category-stiri","tag-cancer-pulmonar","tag-cancer-pulmonar-cu-celule-mici","tag-celule-mezenchimale","tag-chimioterapie","tag-dr-anurag-singh","tag-kras","tag-mir-124","tag-nsclc","tag-proto-oncogena"],"yoast_head":"\nSingura molecul\u0103 care determin\u0103 moartea celulelor pulmonare canceroase - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Singura molecul\u0103 care determin\u0103 moartea celulelor pulmonare canceroase - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"Oamenii de \u015ftiin\u0163\u0103 au descoperit c\u0103 o molecul\u0103 numit\u0103 mIR-124 joac\u0103 un rol important \u00een aflarea r\u0103spunsului la \u00eentrebarea dac\u0103\" \/>\n<meta property=\"og:url\" content=\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/\" \/>\n<meta property=\"og:site_name\" content=\"Doctor Expres\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-20T07:28:14+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/doctorexpres.ro\/wp-content\/uploads\/2016\/12\/Cancer-cells.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"461\" \/>\n\t<meta property=\"og:image:height\" content=\"277\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Doctor Expres\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scris de\" \/>\n\t<meta name=\"twitter:data1\" content=\"Doctor Expres\" \/>\n\t<meta name=\"twitter:label2\" content=\"Timp estimat pentru citire\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/\"},\"author\":{\"name\":\"Doctor Expres\",\"@id\":\"https:\/\/doctorexpres.ro\/#\/schema\/person\/28f79c329d023ab5816a649c97121076\"},\"headline\":\"Singura molecul\u0103 care determin\u0103 moartea celulelor pulmonare canceroase\",\"datePublished\":\"2022-09-20T07:28:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/\"},\"wordCount\":283,\"image\":{\"@id\":\"http:\/\/doctorexpres.ro\/index.php\/2022\/09\/20\/singura-molecula-care-determina-moartea-celulelor-pulmonare-canceroase\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/doctorexpres.ro\/wp-content\/uploads\/2016\/12\/Cancer-cells.jpg\",\"keywords\":[\"cancer pulmonar\",\"Cancer pulmonar cu celule mici\",\"celule mezenchimale\",\"chimioterapie\",\"dr. 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