{"id":1945,"date":"2016-07-27T22:06:44","date_gmt":"2016-07-27T22:06:44","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=1945"},"modified":"2016-08-15T20:51:50","modified_gmt":"2016-08-15T20:51:50","slug":"semnele-bolii-parkinson-pot-fi-citite-si-in-ficat","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2016\/07\/27\/semnele-bolii-parkinson-pot-fi-citite-si-in-ficat\/","title":{"rendered":"Semnele bolii Parkinson pot fi \u201ecitite\u201d \u015fi \u00een ficat"},"content":{"rendered":"<p lang=\"ro-RO\" align=\"JUSTIFY\">Indiciile care trimit spre riscul de a dezvolta boala Parkinson se ascund \u00een locuri neobi\u0219nuite, potrivit unui studiu recent. Mici schimb\u0103ri care au loc la nivelul ADN-ului au fost legate de boala Parkinson, a doua cea mai frecvent\u0103 tulburare neurodegenerativ\u0103 dup\u0103 Alzheimer. Aceste modific\u0103ri au fost g\u0103site nu numai \u00een celulele creierului, unde era de a\u0219teptat, ci \u0219i \u00een ficat, gr\u0103sime, sistem imunitar \u015fi celule embrionare. Aceste constat\u0103ri pot contribui la aplicarea de m\u0103suri preventive, \u00eenainte ca manifest\u0103rile bolii s\u0103 devin\u0103 evidente.<!--more--><br \/>\n\u201e<em>C\u00eend am privit datele, am fost destul de surprins s\u0103 constat varietatea tipurilor de \u021besut<\/em>\u201d, a declarat Gerry Coetzee, profesor la Van Andel Research Institute din SUA. \u201e<em>\u00cen cele din urm\u0103, dac\u0103 vom putea defini mai precis factorii de risc pentru maladia Parkinson, vom putea dezvolta metode de a le atenua din timp. Mai avem \u00eenc\u0103 un drum lung de parcurs, dar aceste constat\u0103ri s\u00eent primii pa\u0219i pe acest drum<\/em>\u201d, a spus omul de \u015ftiin\u0163\u0103.<\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\">Cu toate c\u0103 aceste modific\u0103ri, numite polimorfisme unice-nucleotide (SNP), s\u00eent foarte mici, o acumulare suficient\u0103 a acestora poate spori \u00een mod semnificativ riscul unei persoane de a dezvolta Parkinson. Efectul poate fi comparat cu cel al nisipului: un singur fir va avea un efect redus, dar dac\u0103 se adaug\u0103 suficiente fire de nisip, balan\u021ba se va \u00eenclina. Genomul uman con\u0163ine aproximativ 80 de milioane de SNP-uri, multe dintre ele situate \u00een regiuni ale ADN-ului care au fost deja considerate a fi zone \u201eproscrise\u201d. Oamenii de \u015ftiin\u0163\u0103 \u015ftiu acum c\u0103 aceste zone, situate pe ADN \u00een afara genelor, joac\u0103 un rol critic \u00een modularea expresiei genelor \u015fi s\u00eent un instrument util pentru a determina leg\u0103tura unei gene cu func\u021bia sau rolul s\u0103u \u00een boala Parkinson. \u00cen consecin\u0163\u0103, SNP-urile ofer\u0103 o oportunitate unic\u0103 de a r\u0103spunde la una dintre \u00eentreb\u0103rile majore \u00een cercetarea Parkinson: ce cauzeaz\u0103 sau contribuie la declan\u015farea acestei maladii? \u00cen timp ce oamenii de \u015ftiin\u0163\u0103 \u015ftiu c\u0103 5 p\u00een\u0103 la 10% din cazurile de Parkinson s\u00eent transmise genetic, \u00eenc\u0103 nu se cunosc factorii care stau \u00een spatele majorit\u0103\u0163ii cazurilor.<\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\">Teoria predominant\u0103 sus\u0163ine c\u0103 ar fi vorba de un amestec de factori genetici \u0219i de mediu, care ar crea o furtun\u0103 perfect\u0103, ceea ce duce la aglomerarea de proteine anormale care se r\u0103sp\u00eendesc \u00een creier, ucig\u00eend celulele care produc dopamina, vital\u0103 pentru a asigura omului mi\u015fc\u0103ri voluntare.<\/p>\n<p lang=\"ro-RO\" align=\"JUSTIFY\">Sursa: <a href=\"http:\/\/medicalxpress.com\/news\/2016-07-indicators-parkinson-disease-unexpected.html\" target=\"_blank\">medicalxpress.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Indiciile care trimit spre riscul de a dezvolta boala Parkinson se ascund \u00een locuri neobi\u0219nuite, potrivit unui studiu recent. Mici<\/p>\n","protected":false},"author":4,"featured_media":1946,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[818,91],"tags":[2070,2071,2074,1890,2075,2072,2073],"class_list":["post-1945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-creier-si-sistem-nervos","category-stiri","tag-boala-parkinson","tag-factori-genetici-in-parkinson","tag-ficatul-si-boala-parkinson","tag-modificari-genetice","tag-modificari-parkinson","tag-proteine-anormale","tag-tulburare-neurodegenerativa"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Semnele bolii Parkinson pot fi \u201ecitite\u201d \u015fi \u00een ficat - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doctorexpres.ro\/index.php\/2016\/07\/27\/semnele-bolii-parkinson-pot-fi-citite-si-in-ficat\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Semnele bolii Parkinson pot fi \u201ecitite\u201d \u015fi \u00een ficat - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"Indiciile care trimit spre riscul de a dezvolta boala Parkinson se ascund \u00een locuri neobi\u0219nuite, potrivit unui studiu recent. 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