{"id":2047,"date":"2023-02-16T21:02:02","date_gmt":"2023-02-16T19:02:02","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=2047"},"modified":"2023-02-16T21:03:36","modified_gmt":"2023-02-16T19:03:36","slug":"turele-de-noapte-sporesc-riscul-de-cancer","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2023\/02\/16\/turele-de-noapte-sporesc-riscul-de-cancer\/","title":{"rendered":"Turele de noapte sporesc riscul de cancer"},"content":{"rendered":"<p align=\"JUSTIFY\">Un nou studiu a descoperit o leg\u0103tur\u0103 \u00eentre perturbarea ritmului circadian \u015fi cre\u015fterea tumorilor. Ceasul circadian guvernat de lumin\u0103 reglementeaz\u0103 calendarul fiziologiei umane, prin controlul activit\u0103\u0163ilor celulare, cum ar fi metabolismul \u0219i diviziunea. O serie de studii asupra factorilor de risc \u00een cancer a scos la iveal\u0103 c\u0103, persoanele care lucreaz\u0103 \u00een ture de noapte, ceea ce \u00eenseamn\u0103 aproape 15% dintre americani, prezint\u0103 riscuri sporite de a dezvolta<a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/07\/08\/test-genetic-care-depisteaza-recidiva-cancerului\/\" target=\"_blank\" rel=\"noopener noreferrer\"> cancer<\/a>. Biologii de la <span lang=\"ro-RO\">Massachusetts Institute of Technology<\/span> au descoperit acum o leg\u0103tur\u0103 care ar putea explica acest risc ridicat.<!--more--><\/p>\n<p align=\"JUSTIFY\">\u00centr-un studiu pe \u015foareci, echipa de la MIT a constatat c\u0103 dou\u0103 dintre genele care controleaz\u0103 ritmul circadian al celulelor func\u021bioneaz\u0103 \u0219i ca supresori tumorali. Pierderea acestor distrug\u0103tori ai tumorilor, fie prin extirparea genei, fie prin perturbarea ciclului normal lumin\u0103\/\u00eentuneric, permite tumorilor s\u0103 devin\u0103 mai agresive. \u201e<em>Pierderea pare a conduce la tumorigenez\u0103<\/em>\u201d, precizeaz\u0103 Thales Papagiannakopoulos, profesor asistent de patologie la Universitatea de Medicin\u0103 din New York \u015fi autorul principal al studiului.<\/p>\n<p align=\"JUSTIFY\">La om, ceasul circadian central este localizat \u00een nucleii suprachiasmatici ai creierului (NSC), care primesc informa\u021bii cu privire la intensitatea luminii de la nivelul retinei. NSC comunic\u0103 aceste informa\u021bii celulelor din organism, prin hormoni si alte molecule de semnalizare. \u00cen interiorul celulelor, o gen\u0103 numit\u0103 Bmal1 este responsabil\u0103 pentru activarea altor gene care controleaz\u0103 activit\u0103\u0163ile circadiene, printre care \u015fi una numit\u0103 Per2. Nivelurile de proteine codificate de aceste gene oscileaz\u0103 \u00een mod normal pe tot parcursul zilei, dar c\u00eend ciclurile lumin\u0103\/\u00eentuneric normale s\u00eent perturbate, aceste oscila\u021bii dispar.<\/p>\n<p align=\"JUSTIFY\">\u201e<em>Celulele au nevoie de acest buton de resetare. C\u00eend \u00eel pierzi, pierzi ritmurile normale \u00een fiecare celul\u0103 din corp<\/em>\u201d, spune Papagiannakopoulos. El \u015fi colegii s\u0103i au investigat o posibil\u0103 leg\u0103tur\u0103 \u00eentre <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/07\/obiceiuri-alimentare-care-lupta-cu-cancerul\/\" target=\"_blank\" rel=\"noopener noreferrer\">cancer<\/a> \u015fi aceste gene, la \u015foareci predispu\u015fi s\u0103 dezvolte cancer pulmonar cu celule non-mici.<\/p>\n<p align=\"JUSTIFY\">\u00cen cadrul cercet\u0103rii, un grup de \u015foareci a tr\u0103it cu un program normal de 12 ore de lumin\u0103, urmat de 12 ore de \u00eentuneric, \u00een timp ce ceilal\u021bi \u0219oareci, la fiecare dou\u0103-trei zile, au fost expu\u015fi la \u00eenc\u0103 opt ore de lumin\u0103. Acest lucru imit\u0103 perturbarea ceasului biologic care are loc atunci c\u00eend oamenii lucreaz\u0103 \u00een <strong>ture de noapte<\/strong> sau c\u0103l\u0103toresc prin mai multe zone cu<strong> fusuri orare<\/strong> diferite. La cel de-al doilea grup, tumorile au crescut mai repede si au fost mai agresive dec\u00eet la \u015foarecii cu orar normal.<\/p>\n<p align=\"JUSTIFY\">\u00cen urm\u0103torul set de experimente, cercet\u0103torii au p\u0103strat <strong>regimul lumin\u0103\/\u00eentuneric<\/strong> normal, dar au scos genele Bmal1 \u0219i Per2. La ace\u015fti \u015foareci, tumorile au crescut mai repede. Bmal1 \u0219i Per2 controleaz\u0103 producerea unei proteine responsabile de dezvoltarea cancerului, cunoscut\u0103 sub numele de c-myc, astfel \u00eenc\u00eet atunci c\u00eend aceste gene s\u00eent perturbate, c-myc \u00eencepe s\u0103 se acumuleze, stimul\u00eend o cre\u0219tere a metabolismului celular si proliferarea cancerului.<\/p>\n<p align=\"JUSTIFY\">Joseph Takahashi, pre\u015fedintele Departamentului de Neuro\u015ftiin\u0163e de la Universitatea Texas Southwestern Medical Center, spune c\u0103 studiul ofer\u0103 o important\u0103 leg\u0103tur\u0103 \u00eentre cancer \u015fi disfunc\u0163iile ceasului circadian.<\/p>\n<p align=\"JUSTIFY\">Cercet\u0103torii au analizate probe de<a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/07\/24\/patrunjelul-uscat-opreste-metastazele\/\" target=\"_blank\" rel=\"noopener noreferrer\"> tumori pulmonare umane<\/a> \u015fi au constatat niveluri mult mai sc\u0103zute ale genei Bmal1 \u0219i Per2 dec\u00eet \u00een \u0163esuturile pacien\u0163ilor normali. Tumorile cele mai agresive au avut un nivel chiar \u015fi mai mic al acestor gene.<\/p>\n<p align=\"JUSTIFY\">Papagiannakopoulos investigheaz\u0103 acum dac\u0103 c<a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/07\/28\/curcumina-inhiba-dezvoltarea-celulelor-canceroase\/\" target=\"_blank\" rel=\"noopener noreferrer\">elulele canceroase<\/a> care au un ritm circadian perturbat prin pierderea Bmal1 \u0219i Per2 au puncte slabe care ar putea fi exploatate ca \u021binte poten\u021biale ale medicamentelor. De asemenea, el inten\u021bioneaz\u0103 s\u0103 studieze modul \u00een care modific\u0103rile ceasului circadian afecteaz\u0103 alte tipuri de cancer, ca de exemplu cancerul pancreatic.<\/p>\n<p align=\"JUSTIFY\"><span lang=\"ro-RO\">Articolul integral \u00een <a href=\"http:\/\/medicalxpress.com\/news\/2016-07-reveals-link-circadian-clock-disruption.html\" target=\"_blank\" rel=\"noopener noreferrer\">medicalxpress.com<\/a><br \/>\n<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un nou studiu a descoperit o leg\u0103tur\u0103 \u00eentre perturbarea ritmului circadian \u015fi cre\u015fterea tumorilor. Ceasul circadian guvernat de lumin\u0103 reglementeaz\u0103<\/p>\n","protected":false},"author":4,"featured_media":2048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[93,106,91],"tags":[1972,1969,1967,1968,1973,1970,1971],"class_list":["post-2047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-la-birou","category-stiri","tag-activitati-circadiene","tag-fusurile-orare-si-sanatatea","tag-munca-de-noapte","tag-regimul-lumina-intuneric","tag-risc-de-cancer-la-cei-ce-lucreaza-noaptea","tag-tumori-pulmonare","tag-ture-de-noapte"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Turele de noapte sporesc riscul de cancer - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doctorexpres.ro\/index.php\/2023\/02\/16\/turele-de-noapte-sporesc-riscul-de-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Turele de noapte sporesc riscul de cancer - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"Un nou studiu a descoperit o leg\u0103tur\u0103 \u00eentre perturbarea ritmului circadian \u015fi cre\u015fterea tumorilor. 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