{"id":5296,"date":"2017-01-27T19:32:33","date_gmt":"2017-01-27T19:32:33","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=5296"},"modified":"2017-01-27T19:33:42","modified_gmt":"2017-01-27T19:33:42","slug":"anumite-deficiente-din-autism-pot-fi-tratate-cu-antibiotic","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2017\/01\/27\/anumite-deficiente-din-autism-pot-fi-tratate-cu-antibiotic\/","title":{"rendered":"Anumite deficien\u0163e din autism pot fi tratate cu antibiotic"},"content":{"rendered":"

Un antibiotic utilizat pentru tratarea tuberculozei ar putea atenua deficien\u0163ele sociale asociate cu tulbur\u0103ri din spectrul autismului.
\nStudiul american arat\u0103 c\u0103 medicamentul d-cycloserine amplific\u0103 func\u0163ia genei PCDH10 legat\u0103 de autism<\/a> \u015fi \u00eembun\u0103t\u0103\u0163e\u015fte deficien\u0163ele sociale la \u015foareci. Autorul principal, prof. Edward Brodkin, de la Universitatea din Pennsylvania, \u015fi colegii s\u0103i au publicat aceste concluzii \u00een revista Psihiatria Biologic\u0103.<\/p>\n

Tulburarea din spectrul autismului<\/a> (ASD) este caracterizat\u0103 prin probleme la nivelul abilit\u0103\u0163ilor sociale, \u00een sfera comunic\u0103rii \u015fi comportamentului. Centrul pentru Controlul \u015fi Prevenirea Bolilor estimeaz\u0103 c\u0103 aproximativ 1 din 68 de copii din SUA au ASD, iar afec\u0163iunea este de aproximativ 4,5 ori mai frecvent\u0103 \u00een r\u00eendul b\u0103ie\u0163ilor dec\u00eet al fetelor.<\/p>\n

O gen\u0103 asociat\u0103 autismului este PCDH10, este situat\u0103 \u00een amigdal\u0103<\/a>, o regiune a creierului care a fost legat\u0103 de deficien\u0163ele sociale \u015fi comportamentale la persoanele cu autism. Cu toate acestea, nu se cunoa\u015fte exact modul \u00een care aceast\u0103 gen\u0103 afecteaz\u0103 activitatea neuronal\u0103 \u00een amigdal\u0103 pentru a influen\u0163a comportamentul social.
\nPentru studiul lor, cercet\u0103torii au analizat neuronii<\/a> din amigdala \u015foarecilor priva\u0163i de gena PCDH10. S-a descoperit c\u0103 ace\u015fti neuroni au ar\u0103tat o reducere a nivelului receptorului glutamat NMDA, un indicator al perturb\u0103rii conectivit\u0103\u0163ii \u00een circuitele neuronale. Roz\u0103toarele au prezentat deficite sociale, confirm\u00eend rolul PCDH10 \u00een comportamentul social.<\/p>\n

Interesant, comportamentul social al \u015foarecilor masculi a fost mai afectat de reducerea func\u0163iei PCDH10 dec\u00eet femelele, ceea ce se coreleaz\u0103 cu inciden\u0163a mai mare a ASD la persoanele de gen masculin.<\/p>\n

\u00cen continuare, cercet\u0103torii au tratat \u015foarecii cu d-cycloserine (seromicin\u0103), un antibiotic prescris \u00een tratamentul tuberculozei <\/a>\u015fi al infec\u0163iilor tractului urinar.<\/a> D-cycloserine este cunoscut pentru stimularea func\u0163iei receptorului glutamat NMDA, iar studiile anterioare au sugerat c\u0103 medicamentul poate fi eficace \u00een tulbur\u0103rile de anxietate<\/a>. \u00cen urma tratamentului cu d-cycloserine, cercet\u0103torii au identificat o \u00eembun\u0103t\u0103\u0163ire a deficien\u0163elor sociale la roz\u0103toare<\/a>.
\nNu numai c\u0103 acest studiu pune \u00een lumin\u0103 mecanismele prin care PCDH10 contribuie la deficitele sociale din ASD, dar indic\u0103, de asemenea un poten\u0163ial tratament pentru astfel de deficien\u0163e.
\nCu toate acestea, prof. Brodkin constat\u0103 c\u0103 s\u00eent necesare mai multe studii la animale \u015fi la om, \u00eenainte ca d-cycloserine s\u0103 poat\u0103 fi recomandat\u0103 ca tratament sigur \u015fi eficient pentru ASD.
\nSursa: medicalnewstoday.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Un antibiotic utilizat pentru tratarea tuberculozei ar putea atenua deficien\u0163ele sociale asociate cu tulbur\u0103ri din spectrul autismului.<\/p>\n","protected":false},"author":4,"featured_media":5297,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[96,818,86,91],"tags":[6948,6159,6955,780,1426,6954,6953,6946,6956,6950,6949,6951,6952,6945,1685,6947],"class_list":["post-5296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boli","category-creier-si-sistem-nervos","category-mame-si-copii","category-stiri","tag-activitate-neuronala","tag-amigdala","tag-antibiotic-tuberculoza","tag-asd","tag-autism","tag-cicloserina","tag-d-cycloserine","tag-deficiente-sociale","tag-medicament-autism","tag-nmda","tag-pcdh10","tag-receptor-glutamat","tag-seromicina","tag-tulburare-din-spectrul-autismului","tag-tulburari-de-comportament","tag-tulburari-de-comunicare"],"yoast_head":"\nAnumite deficien\u0163e din autism pot fi tratate cu antibiotic - 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