{"id":5849,"date":"2017-03-09T21:27:22","date_gmt":"2017-03-09T21:27:22","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=5849"},"modified":"2017-03-09T21:29:07","modified_gmt":"2017-03-09T21:29:07","slug":"a-fost-descoperita-o-populatie-cu-toleranta-la-arsenic","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2017\/03\/09\/a-fost-descoperita-o-populatie-cu-toleranta-la-arsenic\/","title":{"rendered":"A fost descoperit\u0103 o popula\u0163ie cu toleran\u0163\u0103 la arsenic"},"content":{"rendered":"<p style=\"text-align: justify;\">\u00cen regiunea Quebrada Camarones din de\u0219ertul Atacama, Chile, unul dintre cele mai uscate de\u015ferturi din lume, mediul este foarte ostil omului: apa se g\u0103e\u015fte greu, iar \u00een r\u00eeuri \u0219i f\u00eent\u00eeni, arsenicul \u00eenregistreaz\u0103 o rat\u0103 de 1 microgram pe litru, concentra\u021bie de 100 de ori mai mare dec\u00eet limita de siguran\u021b\u0103 stabilit\u0103 de Organiza\u021bia Mondial\u0103 a S\u0103n\u0103t\u0103\u0163ii. <!--more--><\/p>\n<p style=\"text-align: justify;\">Concentra\u0163ia mare se datoreaz\u0103 unui fenomen natural: arsenicul din rocile vulcanice este eliberat \u00een p\u00eenza freatic\u0103, transform\u00eend lichidul vital \u00eentr-o otrav\u0103 mortal\u0103. Cu toate acestea, oamenii n-au ocolit acest \u0163inut ostil, pe care continu\u0103 s\u0103-l locuiasc\u0103 de circa 7.000 de ani. Cum au supravie\u021buit?<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-5850 alignright\" src=\"http:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/w453-80557-Carte-238x300.png\" alt=\"w453-80557-Carte\" width=\"202\" height=\"254\" srcset=\"https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/w453-80557-Carte-238x300.png 238w, https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/w453-80557-Carte.png 453w\" sizes=\"auto, (max-width: 202px) 100vw, 202px\" \/>Oamenii de \u015ftiin\u0163\u0103 au deslu\u015fit misterul <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/08\/corpul-nostru-are-nevoie-de-arsenic\/\" target=\"_blank\">adapt\u0103rii la arsenic<\/a>. Prof. Mario Apata \u015fi colegii s\u0103i de la Universitatea din Santiago de Chile au analizat codul genetic a aproape 150 de persoane din trei regiuni diferite: Arica Azapa Valley-Quebrada Camarones-Antofagasta, San Antonio de los Cobres \u0219i San Juan de la Costa. Rezultatele au fost publicate \u00een februarie 2017, \u00een American Journal of Physical Anthropology.<\/p>\n<p style=\"text-align: justify;\">Oamenii de \u015ftiin\u0163\u0103 au analizat varia\u021biile <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/11\/06\/au-fost-descoperite-genele-care-controleaza-visele\/\" target=\"_blank\">genei<\/a> AS3MT, prezent\u0103 pe cromozomul 10. AS3MT codific\u0103 o enzim\u0103 care metabolizeaz\u0103 arsenicul \u00een doi compu\u0219i: acid monometilarsonic (MMA) \u0219i acid dimetilarsinic (DMA). Cei care elimin\u0103 arsenic \u00een urin\u0103 convertesc mai eficient <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/03\/01\/alimentele-fara-gluten-pline-de-mercur-si-arsenic\/\" target=\"_blank\">arsenicul<\/a> \u00een DMA, compus mai pu\u021bin toxic.<\/p>\n<p style=\"text-align: justify;\">Concluzia a fost c\u0103 muta\u0163ia genetic\u0103 observat\u0103, cauza sintezei crescute de DMA, a fost mai frecvent\u0103 \u00een <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/07\/28\/de-ce-in-comunitatile-amish-nu-exista-cancer-diabet-si-autism\/\" target=\"_blank\">popula\u021bia <\/a>din Quebrada Camarones (68%, fa\u021b\u0103 de 48% \u0219i 8% \u00een celelalte dou\u0103 regiuni studiate). \u201e<em>O capacitate mare pentru <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/09\/12\/exercitii-care-imbunatatesc-metabolismul-in-10-minute\/\" target=\"_blank\">metabolismul<\/a> arsenicului a fost probabil aleas\u0103 ca mecanism de adaptare pentru a supravie\u021bui \u00een acest mediu<\/em>\u201d, spun cercet\u0103torii \u00een studiul lor. Muta\u0163ia care protejeaz\u0103 popula\u021bia din Quebrada Camarones vizeaz\u0103 o singur\u0103 liter\u0103 a ADN-ului din codul genetic (oamenii de \u0219tiin\u021b\u0103 vorbesc de \u201epolimorfismului unei singure nucleotide\u201d). O schimbare mic\u0103, dar care \u00eempiedic\u0103 acum oamenii de \u0219tiin\u021b\u0103 s\u0103 \u00een\u021beleag\u0103 modul \u00een care schimb\u0103 enzima la nivel molecular.<\/p>\n<p style=\"text-align: justify;\">Potrivit oamenilor de \u0219tiin\u021b\u0103, <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/08\/dopajul-viitorului-manipularea-genetica\/\" target=\"_blank\">muta\u021biile genetice <\/a>pe AS3MT s\u00eent prezente \u00een \u00eentreaga lume, dar s\u00eent distribuite cu frecven\u021be mai mari \u00een Anzi, Argentina \u015fi Vietnam, regiuni cu concentra\u0163ii foarte mari de arsenic \u00een ap\u0103. Cercet\u0103torii fac o paralel\u0103 \u00eentre toleran\u0163a la arsenic \u015fi lactoz\u0103: o muta\u0163ie \u00een enzima lactaz\u0103, util\u0103 pentru digestia <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/12\/20\/11-feluri-de-lapte-de-post\/\" target=\"_blank\">laptelui<\/a>, a ap\u0103rut aproximativ 7.000 de ani. 35% dintre adul\u0163ii din lume au \u00een prezent aceast\u0103 muta\u021bie.<\/p>\n<p style=\"text-align: justify;\">\u201e<em>Frecven\u021ba mai ridicat\u0103 a <a href=\"http:\/\/doctorexpres.ro\/index.php\/2017\/01\/24\/plantele-modificate-genetic-un-rau-cu-care-ne-am-obisnuit\/\" target=\"_blank\">muta\u0163iilor<\/a> protectoare \u00een popula\u021biile nordice din Chile indic\u0103 o expunere \u00eendelungat\u0103 la <a href=\"http:\/\/doctorexpres.ro\/index.php\/2016\/08\/09\/ungaria-importa-apa-nepoluata-din-romania\/\" target=\"_blank\">sursele de ap\u0103 contaminate<\/a> \u00een mod natural cu arsenic. Datele noastre sugereaz\u0103 c\u0103 o mare capacitate de metabolizare a arsenicului a fost selectat\u0103 ca mecanism de adaptare, \u00een scopul de a supravie\u021bui \u00eentr-un mediu \u00eenc\u0103rcat de arsenic<\/em>.\u201d<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\" wp-image-5852 alignright\" src=\"http:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/desert-art04-300x201.jpg\" alt=\"desert-art04\" width=\"275\" height=\"184\" srcset=\"https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/desert-art04-300x201.jpg 300w, https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/03\/desert-art04.jpg 608w\" sizes=\"auto, (max-width: 275px) 100vw, 275px\" \/>Quebrada Camarones este o zon\u0103 renumit\u0103 pentru geoglifele l\u0103sate de popoarele precolumbiene (inca\u015fi), similare celor din C\u00eempia Nazca. Se presupune c\u0103 au o vechime de 2.500 de ani. \u00cen de\u015fertul Atacama s\u00eent peste 5.000 de astfel de geoglife. Cea mai mare are 117 metri \u015fi e denumit\u0103 Uria\u015ful din Chiza.<\/p>\n<p style=\"text-align: justify;\">Sursa: <a href=\"https:\/\/www.sciencesetavenir.fr\/sante\/comment-les-populations-du-desert-d-atacama-se-sont-adaptees-a-l-arsenic_110979\" target=\"_blank\">sciencesetavenir.fr<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00cen regiunea Quebrada Camarones din de\u0219ertul Atacama, Chile, unul dintre cele mai uscate de\u015ferturi din lume, mediul este foarte ostil<\/p>\n","protected":false},"author":4,"featured_media":5851,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[98,109,128,108,91],"tags":[8067,8066,1496,8065,8062,8072,8071,8063,8070,8068,8064,8061,8069],"class_list":["post-5849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-controverse","category-factori-naturali","category-hidratarea","category-poluare","category-stiri","tag-acid-dimetilarsinic","tag-acid-monometilarsonic","tag-arsenic","tag-as3mt","tag-concentratia-maxima-de-arsenic","tag-geoglife-atacama","tag-lactaza","tag-mario-apata","tag-metabolismul-arsenicului","tag-mutatie-genetica","tag-otravire-cu-arsenic","tag-quebrada-camarones","tag-rezistenta-la-arsenic"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - 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