{"id":6391,"date":"2017-05-03T19:42:05","date_gmt":"2017-05-03T19:42:05","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=6391"},"modified":"2017-05-03T19:42:05","modified_gmt":"2017-05-03T19:42:05","slug":"medicament-care-tine-loc-de-antrenament","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/03\/medicament-care-tine-loc-de-antrenament\/","title":{"rendered":"Medicament care \u0163ine loc de antrenament"},"content":{"rendered":"

\u00cen fiecare s\u0103pt\u0103m\u00een\u0103, apar noi studii despre beneficiile mi\u015fc\u0103rii asupra s\u0103n\u0103t\u0103\u0163ii. Asta e minunat, dar dac\u0103 nu po\u0163i alerga<\/a>? Pentru persoanele \u00een v\u00eerst\u0103, obeze sau cu mobilitate limitat\u0103, recompensele exerci\u0163iilor fizice s\u00eent inaccesibile.<\/p>\n

Oamenii de \u0219tiin\u021b\u0103 de la Salk Institute (San Diego, California) au descoperit cum poate fi complet activat\u0103 calea genetic\u0103 de declan\u015fare a alerg\u0103rii <\/a>la \u0219oarecii sedentari, cu ajutorul unui compus chimic, care mimeaz\u0103 efectele benefice ale exerci\u021biului fizic, cum ar fi accelerarea arderii gr\u0103similor \u015fi cre\u015fterea rezisten\u0163ei organismului. Studiul, care apare \u00een revista \u201eMetabolismul celular\u201d din 2 mai 2017, nu numai c\u0103 aprofundeaz\u0103 \u00een\u021belegerea rezisten\u021bei, dar \u015fi ofer\u0103 persoanelor cu afec\u021biuni cardiace, boli pulmonare, diabet de tip 2 sau alte probleme de s\u0103n\u0103tate speran\u021ba de a ob\u021bine farmacologic aceste beneficii.<\/p>\n

\u201eEste bine cunoscut faptul c\u0103 oamenii \u00ee\u015fi pot \u00eembun\u0103t\u0103\u0163i rezisten\u0163a fizic\u0103 prin antrenament<\/em>\u201d, spune autorul principal Ronald Evans, cercet\u0103tor la Institutul Medical Howard Hughes. \u201e\u00centrebarea a fost: cum func\u021bioneaz\u0103 rezisten\u021ba \u015fi dac\u0103, \u00een\u021belegem acest lucru, atunci am putea \u00eenlocui antrenamentul cu un medicament<\/a>?<\/em>\u201d<\/p>\n

Dezvoltarea rezisten\u0163ei \u00eenseamn\u0103 a putea sus\u0163ine o activitate aerobic\u0103 pentru perioade mai lungi de timp. Pe m\u0103sur\u0103 ce oamenii devin mai antrena\u0163i, mu\u015fchii trec de la arderea carbohidra\u0163ilor (glucoz\u0103) la arderea gr\u0103similor. Astfel, cercet\u0103torii au presupus c\u0103 rezisten\u0163a la efort este o func\u021bie a abilit\u0103\u021bii sporite a organismului de a arde gr\u0103simea. Un studiu anterior a ar\u0103tat c\u0103 \u015foarecii proiecta\u0163i genetic s\u0103 aib\u0103 activat\u0103 permanent gena PPARD au devenit alerg\u0103tori<\/a> pe distan\u0163e lungi, rezisten\u0163i la cre\u015fterea \u00een greutate<\/a> \u015fi cu un r\u0103spuns \u00eenalt la insulin\u0103, adic\u0103 acele calit\u0103\u0163i asociate cu fitnessul fizic. Echipa a constatat c\u0103 un compus chimic numit GW1516 (GW) a activat PPARD, dar nu a afectat rezisten\u0163a (timpul de alergare).<\/p>\n

\u00cen studiul actual, echipa de la Salk a administrat \u0219oarecilor normali o doz\u0103 mai mare de GW, pentru o perioad\u0103 mai lung\u0103 de timp (8 s\u0103pt\u0103m\u00eeni, \u00een loc de 4). At\u00eet \u0219oarecii care au primit compusul, c\u00eet \u0219i cei care nu l-au primit erau sedentari<\/a>, dar to\u021bi au fost supu\u0219i testelor pentru a vedea c\u00eet timp ar putea alerga p\u00een\u0103 la epuizare.<\/p>\n

\u0218oarecii din grupul de control au alergat aproximativ 160 de minute \u00eenainte de epuizare. \u0218oarecii care au luat medicamentul au alergat pe roat\u0103 270 de minute, cu aproximativ 70% mai mult. Pentru ambele grupuri, epuizarea a fost stabilit\u0103 atunci c\u00eend zah\u0103rul din s\u00eenge <\/a>(glucoza) a sc\u0103zut la aproximativ 70 mg\/dl, ceea ce sugereaz\u0103 c\u0103 nivelurile sc\u0103zute de glucoz\u0103 (hipoglicemia) s\u00eent responsabile pentru oboseal\u0103.<\/p>\n

S-au g\u0103sit 975 de gene a c\u0103ror expresie s-a schimbat ca r\u0103spuns la medicament.<\/p>\n

\u201eAcest studiu sugereaz\u0103 c\u0103 arderea gr\u0103similor<\/a> este mai pu\u0163in un factor de rezisten\u0163\u0103 dec\u00eet un mecanism compensator de conservare a glucozei<\/em>\u201d, spune dr. Michael Downes.<\/p>\n

\u201eSportul activeaz\u0103 PPARD, dar noi demonstr\u0103m c\u0103 pute\u021bi face acela\u0219i lucru f\u0103r\u0103 antrenament fizic<\/a>, ceea ce \u00eenseamn\u0103 c\u0103 v\u0103 pute\u021bi \u00eembun\u0103t\u0103\u021bi rezisten\u021ba la un nivel echivalent cu cel al cuiva care se antreneaz\u0103 <\/a>f\u0103r\u0103 efort fizic<\/em>\u201d, spune Weiwei Fan.<\/p>\n

De\u0219i studiile de laborator au fost efectuate pe \u0219oareci, companiile farmaceutice s\u00eent interesate s\u0103 utilizeze cercetarea pentru a dezvolta studii clinice pe oameni. Echipa se g\u00eende\u015fte la o serie de aplica\u0163ii terapeutice pentru un medicament bazat pe GW, de la cre\u015fterea arderii gr\u0103simii la persoanele care sufer\u0103 de obezitate sau diabet zaharat <\/a>de tip 2, la \u00eembun\u0103t\u0103\u0163irea capacit\u0103\u0163ii pacien\u0163ilor \u00eenainte \u015fi dup\u0103 interven\u0163ia chirurgical\u0103.<\/p>\n

Molecula GW a fost ini\u021bial dezvoltat\u0103 de grupul farmaceutic britanic GlaxoSmithKline (GSK) si Ligand Pharmaceuticals SUA \u00een anii 1990 pentru a trata bolile cardiovasculare \u015fi metabolice. Dar acest tratament experimental a fost abandonat dup\u0103 mai multe studii clinice, din cauza riscului de a provoca cancer<\/a> atunci c\u00eend substan\u021ba este luat\u0103 \u00een doze mari. Substan\u0163a a circulat pe pia\u0163a neagr\u0103 ca supliment alimentar, comercializat sub numele Endurobol, de care au abuzat unii sportivi in timpul Jocurilor Olimpice <\/a>de la Beijing din 2008. \u00cen anul urm\u0103tor, a fost interzis de c\u0103tre Agen\u021bia Mondial\u0103 Antidoping care l-a considerat periculos.<\/p>\n

Sursa: medicalxpress.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00cen fiecare s\u0103pt\u0103m\u00een\u0103, apar noi studii despre beneficiile mi\u015fc\u0103rii asupra s\u0103n\u0103t\u0103\u0163ii. Asta e minunat, dar dac\u0103 nu po\u0163i alerga? Pentru<\/p>\n","protected":false},"author":4,"featured_media":6399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[105,107,91],"tags":[151,9002,9001,8999,9000,1061,8997,9006,1288,9010,9008,9007,8998,9009,9003,9004,9005],"class_list":["post-6391","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-miscare-si-natura","category-sport","category-stiri","tag-alergare","tag-arderea-carbohidratilor","tag-arderea-grasimilor","tag-dr-michael-downes","tag-endurobol","tag-epuizare","tag-gena-ppard","tag-gw1516","tag-hipoglicemie","tag-medicament-in-loc-de-antrenament","tag-medicament-in-loc-de-sport","tag-molecula-gw","tag-nivel-de-glucoza","tag-rezistenta-fizica","tag-rezistenta-la-efort","tag-slabit-cu-medicamente","tag-slabit-fara-sport"],"yoast_head":"\nMedicament care \u0163ine loc de antrenament - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/03\/medicament-care-tine-loc-de-antrenament\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Medicament care \u0163ine loc de antrenament - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"\u00cen fiecare s\u0103pt\u0103m\u00een\u0103, apar noi studii despre beneficiile mi\u015fc\u0103rii asupra s\u0103n\u0103t\u0103\u0163ii. 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