{"id":6443,"date":"2017-05-09T21:29:41","date_gmt":"2017-05-09T21:29:41","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=6443"},"modified":"2017-05-09T21:29:41","modified_gmt":"2017-05-09T21:29:41","slug":"au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/","title":{"rendered":"Au studiat rinichii, dar au aflat cum se formeaz\u0103 inima"},"content":{"rendered":"

Studiul rinichilor de la Universitatea din Virginia, \u015ecoala de Medicin\u0103, a dus \u00een mod nea\u015fteptat la o descoperire despre formarea inimii \u015fi la identificarea unei gene responsabile pentru o boal\u0103 cardiac\u0103 mortal\u0103.<\/p>\n

Cercet\u0103torii americani au fost surprin\u0219i s\u0103 descopere c\u0103 inima<\/a> se formeaz\u0103 \u00een interiorul celulelor stem <\/a>cunoscute sub numele de \u201ecelule precursoare\u201d, care se transform\u0103 \u00een s\u00eenge. Asta \u00eenseamn\u0103 c\u0103 un singur tip de celule stem se transform\u0103 \u00een ambele: s\u00eenge<\/a> \u0219i organul care \u00eel va pompa.<\/p>\n

Cercet\u0103torii au stabilit c\u0103 o gen\u0103 special\u0103, S1P1, este vital\u0103 pentru formarea corect\u0103 a inimii. F\u0103r\u0103 ea, s-ar compromite capacitatea inimii de a se contracta bine \u0219i de a pompa s\u00eenge<\/a> eficient. La oameni, boala e cunoscut\u0103 sub numele de cardiomiopatie ventricular\u0103 non-compactar\u0103, o afec\u0163iune periculoas\u0103 care duce adesea la moarte <\/a>precoce.<\/p>\n

Mul\u021bi pacien\u021bi care sufer\u0103 de boli cronice netratabile, cardiace \u0219i renale, se afl\u0103 pe listele de a\u0219teptare pentru transplant de organe<\/a>. Prin urmare, exist\u0103 o nevoie urgent\u0103 de a \u00een\u021belege ce se \u00eent\u00eempl\u0103 cu celulele \u00een timpul bolii \u0219i cum pot fi reparate.<\/p>\n

Cercet\u0103torii, condu\u015fi de Maria Luisa S. Sequeira-Lopez, de la Centrul de Cercetare a S\u0103n\u0103t\u0103\u0163ii Copilului, investiga modul \u00een care se formeaz\u0103 rinichii, c\u00eend a observat c\u0103 eliminarea genei S1P1 la \u015foareci a avut consecin\u0163e mortale \u00een alt\u0103 parte a corpului. \u201eStudiem rolul acestor gene \u00een dezvoltarea vasculariz\u0103rii rinichiului<\/a>. Inima este primul organ care se dezvolt\u0103 \u015fi astfel, atunci c\u00eend am eliminat gena din aceste celule precursoare, am constatat c\u0103 au ap\u0103rut anomalii ale inimii<\/a>, edem sever, hemoragie \u015fi ritm cardiac sc\u0103zut.<\/em>\u201d<\/p>\n

Apoi, cercet\u0103torii au descoperit c\u0103 \u0219tergerea genei a provocat apari\u021bia unor pere\u021bi sub\u021biri ai inimii<\/a> \u0219i alte probleme cardiace \u00een dezvoltarea embrionilor de \u0219oareci. \u201eDeci a trebuit s\u0103 studiem inima \u00eenainte s\u0103 se formeze rinichii<\/em>.\u201d<\/p>\n

Constat\u0103rile s-au dovedi nea\u015fteptate chiar si pentru oamenii de \u015ftiin\u0163\u0103 speciali\u015fti \u00een dezvoltarea inimii. \u201eDe mult timp se crede c\u0103 fiecare organ se dezvolt\u0103 independent de alte organe, iar inima din anumite celule stem \u015fi s\u00eengele din alte celule stem\u201d, <\/em>a explicat dr. Brian C. Belyea. \u201eDar \u00een aceste celule precursoare exist\u0103 mult mai mult\u0103 plasticitate. Ceea ce am descoperit este c\u0103 celulele precursoare cardiace, care s\u00eent prezente \u00een inima embrionar\u0103, genereaz\u0103 \u00eentr-adev\u0103r componente ale inimii<\/a> la adul\u0163i, dar dau na\u015ftere \u015fi la celulele sanguine<\/a>.<\/em>\u201d<\/p>\n

Cercet\u0103torii au fost at\u00eet de surprin\u0219i de descoperire, \u00eenc\u00eet au repetat de mai multe ori experimentele, folosind tehnici multiple, inclusiv noi tehnici pe care le-au dezvoltat. Rezultatele s-au validat de fiecare dat\u0103.<\/p>\n

Belyea a spus c\u0103 descoperirea despre rolul important al genei S1P1 ar putea \u00eentr-o bun\u0103 zi s\u0103 conduc\u0103 la tratamente mai bune pentru aceast\u0103 afec\u021biune cardiac\u0103.<\/p>\n

Sursa: sciencedaily.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Studiul rinichilor de la Universitatea din Virginia, \u015ecoala de Medicin\u0103, a dus \u00een mod nea\u015fteptat la o descoperire despre formarea<\/p>\n","protected":false},"author":4,"featured_media":6472,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[96,92,91],"tags":[9150,9148,9156,956,9151,9154,9149,9155,9152,9147,9153],"class_list":["post-6443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boli","category-inima-si-sistem-circulator","category-stiri","tag-cardiomiopatie-ventriculara-non-compactara","tag-celule-precursoare","tag-celule-sanguine","tag-celule-stem","tag-celulele-inimii","tag-dr-brian-c-belyea","tag-formarea-inimii","tag-inima-embrionara","tag-maria-luisa-s-sequeira-lopez","tag-s1p1","tag-vascularizarea-rinichiului"],"yoast_head":"\nAu studiat rinichii, dar au aflat cum se formeaz\u0103 inima - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Au studiat rinichii, dar au aflat cum se formeaz\u0103 inima - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"Studiul rinichilor de la Universitatea din Virginia, \u015ecoala de Medicin\u0103, a dus \u00een mod nea\u015fteptat la o descoperire despre formarea\" \/>\n<meta property=\"og:url\" content=\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/\" \/>\n<meta property=\"og:site_name\" content=\"Doctor Expres\" \/>\n<meta property=\"article:published_time\" content=\"2017-05-09T21:29:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/05\/33_724_post_media_qVc1.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"459\" \/>\n\t<meta property=\"og:image:height\" content=\"278\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Doctor Expres\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scris de\" \/>\n\t<meta name=\"twitter:data1\" content=\"Doctor Expres\" \/>\n\t<meta name=\"twitter:label2\" content=\"Timp estimat pentru citire\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/\"},\"author\":{\"name\":\"Doctor Expres\",\"@id\":\"https:\/\/doctorexpres.ro\/#\/schema\/person\/28f79c329d023ab5816a649c97121076\"},\"headline\":\"Au studiat rinichii, dar au aflat cum se formeaz\u0103 inima\",\"datePublished\":\"2017-05-09T21:29:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/\"},\"wordCount\":490,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/doctorexpres.ro\/index.php\/2017\/05\/09\/au-studiat-rinichii-dar-au-aflat-cum-se-formeaza-inima\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/doctorexpres.ro\/wp-content\/uploads\/2017\/05\/33_724_post_media_qVc1.jpeg\",\"keywords\":[\"cardiomiopatie ventriculara non-compactara\",\"celule precursoare\",\"celule sanguine\",\"celule stem\",\"celulele inimii\",\"dr. 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