{"id":8255,"date":"2022-09-09T07:41:37","date_gmt":"2022-09-09T04:41:37","guid":{"rendered":"http:\/\/doctorexpres.ro\/?p=8255"},"modified":"2022-09-08T10:48:52","modified_gmt":"2022-09-08T07:48:52","slug":"boala-alzheimer-ar-putea-fi-declansata-de-afectiuni-ale-altor-organe","status":"publish","type":"post","link":"https:\/\/doctorexpres.ro\/index.php\/2022\/09\/09\/boala-alzheimer-ar-putea-fi-declansata-de-afectiuni-ale-altor-organe\/","title":{"rendered":"Boala Alzheimer ar putea fi declan\u0219at\u0103 de afec\u0163iuni ale altor organe"},"content":{"rendered":"

Boala Alzheimer, cauza principal\u0103 a demen\u021bei<\/a>, se presupune c\u0103 provine din creier. Dar cercet\u0103rile de la Universitatea British Columbia indic\u0103 faptul c\u0103 ar putea fi declan\u0219at\u0103 de afec\u021biuni \u00een alt\u0103 parte a corpului.<\/p>\n

Constat\u0103rile, publicate \u00een Molecular Psychiatry, ofer\u0103 speran\u0163a c\u0103 viitoarele terapii medicamentoase ar putea fi capabile s\u0103 opreasc\u0103 sau s\u0103 \u00eencetineasc\u0103 boala f\u0103r\u0103 a ac\u0163iona direct asupra creierului, care este un obiectiv complex, sensibil \u015fi adesea greu de atins. \u00cen schimb, astfel de medicamente ar putea viza rinichii sau ficatul<\/a>, cur\u0103\u0163ind s\u00eengele de proteinele toxice, \u00eenainte de a ajunge vreodat\u0103 \u00een creier.<\/p>\n

Oamenii de \u0219tiin\u021b\u0103 au demonstrat aceast\u0103 mobilitate, asem\u0103n\u0103toare cu cea a cancerului, printr-o tehnic\u0103 numit\u0103 parabioz\u0103: se ata\u0219eaz\u0103 chirurgical dou\u0103 specimene \u00eempreun\u0103, astfel \u00eenc\u00eet acestea s\u0103 aib\u0103 aceea\u0219i rezerv\u0103 de s\u00eenge<\/a> pentru c\u00eeteva luni.<\/p>\n

Profesorul de psihiatrie Weihong Song \u015fi profesorul de neurologie Yan-Jiang Wang de la Universitatea Militar\u0103 din Chongqing au ata\u015fat \u015foareci normali, care nu dezvolt\u0103 \u00een mod natural boala Alzheimer, la \u015foareci modifica\u0163i pentru a transporta o gen\u0103 uman\u0103 mutant\u0103 care produce niveluri ridicate de proteine numite beta-amiloid. La persoanele care sufer\u0103 de boala Alzheimer<\/a>, aceast\u0103 protein\u0103 formeaz\u0103 \u00een cele din urm\u0103 aglomer\u0103ri, sau pl\u0103ci, care afecteaz\u0103 celulele creierului.<\/p>\n

\u015eoarecii obi\u0219nui\u021bi care au fost al\u0103tura\u021bi partenerilor modifica\u021bi genetic<\/a>, pentru un an, au contractat boala Alzheimer. Song spune c\u0103 beta-amiloidul a c\u0103l\u0103torit de la \u0219oarecii modifica\u021bi genetic la creierul partenerilor normali, unde s-a acumulat \u0219i a \u00eenceput s\u0103 provoace daune.<\/p>\n

Nu numai c\u0103 \u015foarecii normali au dezvoltat pl\u0103ci, dar \u0219i o patologie similar\u0103 cu \u201enodurile\u201d (firele de proteine r\u0103sucite care se formeaz\u0103 \u00een interiorul celulelor creierului, perturb\u00eendu-le func\u021bia). Alte semne de leziuni asem\u0103n\u0103toare bolii Alzheimer<\/a>: degenerarea celulelor cerebrale, inflama\u021bia \u0219i microhemoragii. \u00cen plus, abilitatea de a transmite semnale electrice implicate \u00een \u00eenv\u0103\u021bare \u0219i de memorie (semne ale unui creier <\/a>s\u0103n\u0103tos) a fost afectat\u0103.<\/p>\n

Pe l\u00eeng\u0103 creier, beta-amiloidul se produce \u00een trombocite, vase de s\u00eenge \u0219i mu\u0219chi, iar proteina <\/a>precursoare se g\u0103se\u0219te \u00een mai multe organe. Dar, p\u00een\u0103 la aceste experimente, nu era clar dac\u0103 beta-amiloidul din afara creierului ar putea contribui la boala Alzheimer. Acest studiu, spune Song, arat\u0103 c\u0103 poate.<\/p>\n

\u201eBariera hemato-encefalic\u0103 sl\u0103be\u0219te pe m\u0103sur\u0103 ce \u00eemb\u0103tr\u00eenim\u201d, spune Song. \u201eAcest lucru ar putea permite beta-amiloidului s\u0103 infiltreze creierul<\/a>, supliment\u00eend ceea ce este produs de creierul \u00eensu\u0219i \u0219i acceler\u00eend deteriorarea<\/em>\u201d.<\/p>\n

Song prevede un medicament care se va lega de beta-amiloid \u00een organism, marc\u00eendu-l biochimic astfel \u00eenc\u00eet ficatul sau rinichii s\u0103-l poat\u0103 cur\u0103\u021ba.<\/p>\n

\u201eBoala Alzheimer este \u00een mod clar o boal\u0103 a creierului, dar trebuie s\u0103 fim aten\u0163i la \u00eentregul corp pentru a \u00een\u0163elege de unde vine \u015fi cum s\u0103 o oprim<\/em>\u201d, spune cercet\u0103torul.
\nSursa: news-medical.net<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Boala Alzheimer, cauza principal\u0103 a demen\u021bei, se presupune c\u0103 provine din creier. Dar cercet\u0103rile de la Universitatea British Columbia indic\u0103<\/p>\n","protected":false},"author":4,"featured_media":8257,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[96,818,91],"tags":[361,2967,12368,75,12371,2971,12327,12374,380,12372,1890,5449,12369,12373,1023,12370],"class_list":["post-8255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-boli","category-creier-si-sistem-nervos","category-stiri","tag-alzheimer","tag-beta-amiloid","tag-cauza-dementei","tag-creier","tag-degenerarea-celulelor-cerebrale","tag-dementa","tag-inflamatie","tag-invatare","tag-memorie","tag-microhemoragie","tag-modificari-genetice","tag-neuroni","tag-parabioza","tag-semnale-electrice","tag-trombocite","tag-yan-jiang-wang"],"yoast_head":"\nBoala Alzheimer ar putea fi declan\u0219at\u0103 de afec\u0163iuni ale altor organe - Doctor Expres<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/doctorexpres.ro\/index.php\/2022\/09\/09\/boala-alzheimer-ar-putea-fi-declansata-de-afectiuni-ale-altor-organe\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Boala Alzheimer ar putea fi declan\u0219at\u0103 de afec\u0163iuni ale altor organe - Doctor Expres\" \/>\n<meta property=\"og:description\" content=\"Boala Alzheimer, cauza principal\u0103 a demen\u021bei, se presupune c\u0103 provine din creier. 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